Synthesis and Biological Activities Evaluation of Some New 1,2,4-Triazinone Derivatives Bearing Sulfonamide Moiety

Submit Manuscript | http://medcraveonline.com infectious diseases [1-7]. These drugs were the first efficient treatment to be employed systematically for the prevention and cure of bacterial infections [8-11]. One of the first sulfonamides identified by Domagk et al. [8,9] was the red azo dye known as Prontosil [8,9]. It was active against streptococcal infection in vivo. There have been many analogues of sulfanilamide developed as pharmacological agents that display a wide range of biological activities [12,13]. For example, glibenclamide has found use as a hypoglycemic agent, indisulam (E7070) as an anticancer agent, amprenavir and tipranavir are used in HIV therapy, Furosemide as a diuretic, acetazolamide as a carbonic anhydrase inhibitor, and sulfathiazole, sulfaquinoxaline, silver sulfadiazine (silvadene®), sulfasalazine (azulfidine®) and sulfamethoxazole (gantanol®) as an antibacterial agents [7,10,11,14-16]. In addition, dorzolamide, and brinzolamide have been launched as topically acting antiglaucoma pharmacological agents [17,18]. Till date, thousands of sulfonamide derivatives, analogues, and related compounds have been synthesized, which are effective as diuretics, antimalarial, leprosy and antithyroid agents and employed for other diseases [17,19]. Moreover, aryl sulfonamides celecoxib and vadecoxib are used as COX-II inhibitors and anticancer agents [20,21]. Sildenafil was launched in 1998 as an anti-impotence drug and responsible for inhibiting the degradation of cyclic guanosine monophosphate [22]. It has been observed that sulfa drugs show increased biological activity when administered in the form of metal complexes [18,23].